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Denver Broncos vs Arizona Cardinals prediction

NFL · Sunday, October 25, 2026 · 4:05 PM ET · State Farm Stadium · CBS

Result

Final: Denver Broncos 30, Arizona Cardinals 16 (Denver Broncos won). Mel’s pick (Denver Broncos win 62% of the time) was right. Against the spread, Mel’s lean was right.

Mel’s pick

Denver Broncos win 62% of the time in Mel’s Playbook’s default simulation of this game, saved before it started.

Projected score

Denver Broncos 24, Arizona Cardinals 17. 19% of the simulations finished as one-score games.

Mel vs the betting line

Vegas has Denver Broncos −4.5. Mel projects Denver Broncos by 6.2, so the simulation leans Denver Broncos -4.5 against the spread.

The total is 42.5; Mel’s projected 41.1 is right around it.

Recent form

Denver Broncos (4-2) scored 20.8 and allowed 18.8 points a game over their last 5.

Arizona Cardinals (2-4) scored 20 and allowed 32.8 points a game over their last 5.

Based on this season’s stats, injuries, rest, travel and the betting market. Updated Oct 25, 2:28 PM ET.

See the full simulation

Mel’s Playbook Pro shows the range of likely totals and margins, player props and every factor behind the pick, and lets you tune the model (home field, injuries, momentum and more) and re-run the game.

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Every default-model prediction is saved before the game and graded against the final score on our public results page. Simulations are estimates, not guarantees, and this is not betting advice. 21+ where applicable; if gambling is a problem, call 1-800-GAMBLER.