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Tampa Bay Buccaneers vs Carolina Panthers prediction

NFL · Sunday, October 25, 2026 · 1:00 PM ET · Bank of America Stadium · Fox

Result

Final: Tampa Bay Buccaneers 43, Carolina Panthers 13 (Tampa Bay Buccaneers won). Mel’s pick (Carolina Panthers win 63% of the time) was wrong. Against the spread, Mel’s lean was wrong.

Mel’s pick

Carolina Panthers win 63% of the time in Mel’s Playbook’s default simulation of this game, saved before it started.

Projected score

Tampa Bay Buccaneers 20, Carolina Panthers 24. 19% of the simulations finished as one-score games.

Mel vs the betting line

Vegas has Carolina Panthers −3. Mel projects Carolina Panthers by 4.1, so the simulation leans Carolina Panthers -3 against the spread.

The total is 44.5; Mel’s projected 44.1 is right around it.

Recent form

Tampa Bay Buccaneers (1-5) scored 18.4 and allowed 21 points a game over their last 5.

Carolina Panthers (3-2) scored 29.2 and allowed 24.6 points a game over their last 5.

Who’s out

Based on this season’s stats, injuries, rest, travel, weather and the betting market. Updated Oct 25, 11:28 AM ET.

See the full simulation

Mel’s Playbook Pro shows the range of likely totals and margins, player props and every factor behind the pick, and lets you tune the model (home field, injuries, momentum and more) and re-run the game.

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Every default-model prediction is saved before the game and graded against the final score on our public results page. Simulations are estimates, not guarantees, and this is not betting advice. 21+ where applicable; if gambling is a problem, call 1-800-GAMBLER.